Mammalian RNAi for the masses.

  title={Mammalian RNAi for the masses.},
  author={Yang Shi},
  journal={Trends in genetics : TIG},
  volume={19 1},
  • Yang Shi
  • Published 2003 in Trends in genetics : TIG
Just a couple of years ago, only biologists working with plants or Caenorhabditis elegans could use RNA-mediated interference (RNAi) technology to gain insight into gene function. However, the recent groundbreaking discovery that in vitro synthesized, 21- to 23-nucleotide, double-stranded RNAs can act as small interfering RNAs (siRNAs) to elicit gene-specific inhibition in mammalian cells has made RNAi possible in mammalian systems too. Reported only a year ago, mammalian RNAi is already… CONTINUE READING

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