Mammalian MAP kinase signalling cascades

  title={Mammalian MAP kinase signalling cascades},
  author={Lufen Chang and Michael Karin},
Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death. 

MAP kinase pathways

Mitogen-activated protein kinase (MAPK) pathways regulate diverse processes ranging from proliferation and differentiation to apoptosis. Activated by an enormous array of stimuli, they phosphorylate

MAP Kinase Cascades in Antigen Receptor Signaling and Physiology.

  • T. Yasuda
  • Biology
    Current topics in microbiology and immunology
  • 2016
Studies of genetically engineered mice or chemical inhibitors specific to each MAPK signaling pathway revealed that MAPKs have various, but non-redundant physiologically important roles among different families.

Mitogen-activated protein kinases and their role in regulation of cellular processes.

Mitogen-activated protein kinases (MAPKs) are evolutionary conserved enzymes connecting cell-surface receptors to critical regulatory targets within cells. The three major MAPK cascades are known,

Regulatory mechanisms of mitogen-activated kinase signaling

This review of recent advances in understanding the regulation of MAPK cascades and the roles of MAP kinases and their regulators in development and in immune responses is summarized.

Regulatory mechanisms and functions of MAP kinase signaling pathways

It is becoming clear that strict regulation of the MAPK pathways underlies their manifold functions in numerous biological processes.

MAP Kinase Modules in Signaling




Regulation of transcription by MAP kinase cascades.

  • R. Treisman
  • Biology, Computer Science
    Current opinion in cell biology
  • 1996

MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade.

A protein called MP1 (MEK Partner 1) was identified that bound specifically to MEK2 and ERK1 and facilitated their activation and apparently functions as an adapter to enhance the efficiency of the MAP kinase cascade.

A mammalian scaffold complex that selectively mediates MAP kinase activation.

Data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway and selectively enhanced JNK activation by the MLK signaling pathway.

Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.

The findings suggest that the MAPK signaling pathway promotes cell survival by a dual mechanism comprising the posttranslational modification and inactivation of a component of the cell death machinery and the increased transcription of pro-survival genes.

Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors

The molecular mechanisms by which GPCRs signal to the nucleus through this intricate network of second messenger-generating systems and MAPK signaling pathways, thereby affecting the expression of genes whose products influence many biological processes, including normal and aberrant cell growth, are focused on.

A conserved docking motif in MAP kinases common to substrates, activators and regulators

A hitherto unidentified docking motif in MAPKs is revealed that is used in common for recognition of their activators, substrates and regulators and increases the efficiency of the enzymatic reactions.

MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis

It is concluded that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-α at a post-transcriptional level.

MAP kinase pathways in yeast: For mating and more

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

Results suggest that a specific block in the activation of ERK and JNK contributes to defective IL-2 production in clonal anergy.

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.

Loss of MEKK1 expression resulted in a greater apoptotic response of cells to hyperosmolarity and microtubule disruption, and activated JNK normally in response to heat shock, anisomycin, and ultraviolet irradiation.