Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.

@article{Wilks2015MammalianLR,
  title={Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.},
  author={Jeff Wilks and Egil Lien and Amy N. Jacobson and Michael A. Fischbach and Nilofer Qureshi and Alexander V Chervonsky and Tatyana V. Golovkina},
  journal={Cell host & microbe},
  year={2015},
  volume={18 4},
  pages={
          456-62
        }
}
The orally transmitted retrovirus mouse mammary tumor virus (MMTV) requires the intestinal microbiota for persistence. Virion-associated lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), stimulating production of the immunosuppressive cytokine IL-10 and MMTV evasion of host immunity. However, the mechanisms by which MMTV associates with LPS remain unknown. We find that the viral envelope contains the mammalian LPS-binding factors CD14, TLR4, and MD-2, which, in conjunction with… CONTINUE READING
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The Commensal Microbiota and Viral Infection: A Comprehensive Review

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