Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.

@article{Mizutani2005MammalianLA,
  title={Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.},
  author={Yukiko Mizutani and Akio Kihara and Yasuyuki Igarashi},
  journal={The Biochemical journal},
  year={2005},
  volume={390 Pt 1},
  pages={
          263-71
        }
}
The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide synthesis. In the mouse, there are at least five Lass family members, Lass1, Lass2, Lass4, Lass5 and the hitherto uncharacterized Lass6. To investigate specific roles for each Lass member in ceramide synthesis, we cloned these five mouse proteins. Overproduction of any Lass protein in cultured cells resulted in an increase in cellular ceramide, but the ceramide species… 

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