Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration.

@article{Itoh2002MammalianHI,
  title={Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration.},
  author={H. Itoh and A. Komatsuda and H. Ohtani and H. Wakui and H. Imai and K. Sawada and M. Otaka and M. Ogura and A. Suzuki and F. Hamada},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 23},
  pages={
          5931-8
        }
}
There are few reports concerning the sorting mechanisms of mammalian HSP60 into the mitochondria from the cytoplasm. In the present study we investigated the protein import system. Based on immunoblotting and immuno-histochemistry, HSP60 was detected in both the cytoplasm and mitochondria. The purified cytoplasmic HSP60 showed chaperone activity, and the protein was imported into the mitochondria in vitro by a mitochondrial import assay. HSP60 mRNA was increased in the kidney papilla of rats… Expand
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