Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane.

@article{Takida2008MammalianGP,
  title={Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane.},
  author={Satoshi Takida and Yusuke Maeda and Taroh Kinoshita},
  journal={The Biochemical journal},
  year={2008},
  volume={409 2},
  pages={555-62}
}
The GPI (glycosylphosphatidylinositol) moiety is attached to newly synthesized proteins in the lumen of the ER (endoplasmic reticulum). The modified proteins are then directed to the PM (plasma membrane). Less well understood is how nascent mammalian GPI-anchored proteins are targeted from the ER to the PM. In the present study, we investigated mechanisms underlying membrane trafficking of the GPI-anchored proteins, focusing on the early secretory pathway. We first established a cell line that… CONTINUE READING
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