Mammalian GGAs act together to sort mannose 6-phosphate receptors

@article{Ghosh2003MammalianGA,
  title={Mammalian GGAs act together to sort mannose 6-phosphate receptors},
  author={Pradipta Ghosh and Janice M. Griffith and Hans J. Geuze and Stuart A. Kornfeld},
  journal={The Journal of Cell Biology},
  year={2003},
  volume={163},
  pages={755 - 766}
}
The GGAs (Golgi-localized, gamma ear-containing, ADP ribosylation factor-binding proteins) are multidomain proteins implicated in protein trafficking between the Golgi and endosomes. We examined whether the three mammalian GGAs act independently or together to mediate their functions. Using cryo-immunogold electron microscopy, the three GGAs were shown to colocalize within coated buds and vesicles at the trans-Golgi network (TGN) of HeLa cells. In vitro binding experiments revealed multidomain… CONTINUE READING

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