Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex

@inproceedings{Ishiuchi2009MammalianFA,
  title={Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex},
  author={Takashi Ishiuchi and Kazuyo Misaki and Shigenobu Yonemura and Masatoshi Takeichi and Takuji Tanoue},
  booktitle={The Journal of cell biology},
  year={2009}
}
Compartmentalization of the plasma membrane in a cell is fundamental for its proper functions. In this study, we present evidence that mammalian Fat4 and Dachsous1 cadherins regulate the apical plasma membrane organization in the embryonic cerebral cortex. In neural progenitor cells of the cortex, Fat4 and Dachsous1 were concentrated together in a cell-cell contact area positioned more apically than the adherens junction (AJ). These molecules interacted in a heterophilic fashion, affecting… CONTINUE READING
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