Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.

@article{Lieb2002MammalianEG,
  title={Mammalian EGLN genes have distinct patterns of mRNA expression and regulation.},
  author={Mark E Lieb and Keon E Menzies and Maria C. Moschella and Rujing Ni and Mark B. Taubman},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  year={2002},
  volume={80 4},
  pages={421-6}
}
The mammalian EGLN family contains three paralagous genes (EGLN1, EGLN2, and EGLN3) encoding prolyl hydroxylase isoforms that mediate the oxygen-dependent targeting of the transcription factor hypoxia inducible factor alpha to the proteosome. The rat orthologue of EGLN3 (SM-20) exhibits tissue-restricted expression, is induced by growth factors in cultured vascular smooth muscle, and is up-regulated during myogenesis. To determine if all three EGLN genes are coordinately regulated, we examined… CONTINUE READING