Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).

@article{Makarova2003MammalianCI,
  title={Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).},
  author={Olga Makarova and Michael H. Roh and Chia-Jen Liu and Stephanie Laurinec and Ben L Margolis},
  journal={Gene},
  year={2003},
  volume={302 1-2},
  pages={
          21-9
        }
}
Drosophila Crumbs is a transmembrane protein that plays an important role in epithelial cell polarity and photoreceptor development. Overexpression of Crumbs in Drosophila epithelia expands the apical surface and leads to disruption of cell polarity. Drosophila Crumbs also interacts with two other polarity genes, Stardust and Discs Lost. Recent work has identified a human orthologue of Drosophila Crumbs, known as CRB1, that is mutated in the eye disorders, retinitis pigmentosa and Leber… CONTINUE READING
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