Mammalian Circadian Autoregulatory Loop A Timeless Ortholog and mPer1 Interact and Negatively Regulate CLOCK-BMAL1-Induced Transcription

@article{Sangoram1998MammalianCA,
  title={Mammalian Circadian Autoregulatory Loop A Timeless Ortholog and mPer1 Interact and Negatively Regulate CLOCK-BMAL1-Induced Transcription},
  author={Ashvin M Sangoram and L. J. Saez and Marina P. Antoch and Nicholas Gekakis and David Staknis and Andrew Whiteley and Ethan M Fruechte and Martha H Vitaterna and Kazuhiro Shimomura and David P King and Michael W. Young and Charles J. Weitz and Joseph S Takahashi},
  journal={Neuron},
  year={1998},
  volume={21},
  pages={1101-1113}
}
We report the cloning and mapping of mouse (mTim) and human (hTIM) orthologs of the Drosophila timeless (dtim) gene. The mammalian Tim genes are widely expressed in a variety of tissues; however, unlike Drosophila, mTim mRNA levels do not oscillate in the suprachiasmatic nucleus (SCN) or retina. Importantly, hTIM interacts with the Drosophila PERIOD (dPER) protein as well as the mouse PER1 and PER2 proteins in vitro. In Drosophila (S2) cells, hTIM and dPER interact and translocate into the… CONTINUE READING
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