Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

@article{Chaturvedi1999MammalianCI,
  title={Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway},
  author={Priya Chaturvedi and W K Eng and Yuan Zhu and Michael Mattern and R Mishra and Mark Hurle and Xiaolong Zhang and Roland S. Annan and Quinn Lu and Leo F. Faucette and Gilbert F. Scott and Xiaotong Li and Steven A. Carr and Randall K. Johnson and James D. Winkler and Bin-Bing S. Zhou},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={4047-4054}
}
In response to DNA damage and replication blocks, cells activate pathways that arrest the cell cycle and induce the transcription of genes that facilitate repair. In mammals, ATM (ataxia telangiectasia mutated) kinase together with other checkpoint kinases are important components in this response. We have cloned the rat and human homologs of Saccharomyces cerevisiae Rad 53 and Schizosaccharomyces pombe Cds1, called checkpoint kinase 2 (chk2). Complementation studies suggest that Chk2 can… 
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TLDR
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