Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.

@article{Scott1999MammalianBM,
  title={Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian Tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis.},
  author={Ian C Scott and Ira L. Blitz and William N. Pappano and Yasutada Imamura and Timothy G. Clark and Barry M Steiglitz and Carole Lesley Thomas and Sarah A. Maas and Kazuhiko Takahara and Ken W.Y Cho and Daniel S. Greenspan},
  journal={Developmental biology},
  year={1999},
  volume={213 2},
  pages={283-300}
}
Vertebrate bone morphogenetic protein 1 (BMP-1) and Drosophila Tolloid (TLD) are prototypes of a family of metalloproteases with important roles in various developmental events. BMP-1 affects morphogenesis, at least partly, via biosynthetic processing of fibrillar collagens, while TLD affects dorsal-ventral patterning by releasing TGFbeta-like ligands from latent complexes with the secreted protein Short Gastrulation (SOG). Here, in a screen for additional mammalian members of this family of… CONTINUE READING

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