Mammalian ABC transporters in health and disease.

@article{Borst2002MammalianAT,
  title={Mammalian ABC transporters in health and disease.},
  author={Piet Borst and Ronald P.J. Oude Elferink},
  journal={Annual review of biochemistry},
  year={2002},
  volume={71},
  pages={
          537-92
        }
}
The ATP-binding cassette (ABC) transporters are a family of large proteins in membranes and are able to transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. The available outline of the human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease. Major physiological functions of ABC transporters include the transport of lipids, bile salts, toxic compounds, and peptides… 

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