Malpighi and the Discovery of Capillaries

  title={Malpighi and the Discovery of Capillaries},
  author={John Malcolm Pearce},
  journal={European Neurology},
  pages={253 - 255}
  • J. Pearce
  • Published 12 September 2007
  • Biology
  • European Neurology
Leonardo da Vinci clearly observed and described capillaries. Using the microscope, Marcello Malpighi examined the brain and major organs to demonstrate their finer anatomical features. This led to his discovery in 1661, of capillaries that proved fundamental to our understanding of the vascular system in the brain and cord. He hypothesized that capillaries were the connection between arteries and veins that allowed blood to flow back to the heart in the circulation of the blood, as first… 

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Johann Jakob Wepfer (1620-95) and cerebral haemorrhage.

  • J. Pearce
  • Medicine
    Journal of neurology, neurosurgery, and psychiatry
  • 1997
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Microscopical observations concerning blood , milk , bones , the brain , spittle , and cuticula

  • Philos Trans
  • 1674

Engl transl from Bagvili's Practice of Physik

  • Major RH: Classic Descriptions of Disease

Historiae apoplecticorum, 1658, Engl transl from Bagvili’s Practice of Physik, London, 1704, cited in Major RH

  • Clas sic Descriptions of Disease,
  • 1945