Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.

  title={Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity.},
  author={N. Ruderman and A. Saha and D. Vavvas and T. Kurowski and D. R. Laybutt and C. Schmitz-Peiffer and T. Biden and E. Kraegen},
  journal={Advances in experimental medicine and biology},
  • N. Ruderman, A. Saha, +5 authors E. Kraegen
  • Published 1998
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • Malonyl CoA is a regulator of carnitine palmitoyl transferase 1 (CPT1), the enzyme that controls the transfer of long chain fatty acyl CoA into mitochondria where it is oxidized. Recent studies indicate that in skeletal muscle the concentration of malonyl CoA is acutely (minutes) regulated by changes in its fuel supply and energy expenditure. In response to changes in fuel supply, regulation appears to be due to alterations in the cytosolic concentration of citrate, which is both an allosteric… CONTINUE READING
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