Malonyl-CoA, fuel sensing, and insulin resistance.

@article{Ruderman1999MalonylCoAFS,
  title={Malonyl-CoA, fuel sensing, and insulin resistance.},
  author={Neil Bertrand Ruderman and A K Saha and Demetrios G Vavvas and Lee Alan Witters},
  journal={The American journal of physiology},
  year={1999},
  volume={276 1 Pt 1},
  pages={E1-E18}
}
Malonyl-CoA is an allosteric inhibitor of carnitine palmitoyltransferase (CPT) I, the enzyme that controls the transfer of long-chain fatty acyl (LCFA)-CoAs into the mitochondria where they are oxidized. In rat skeletal muscle, the formation of malonyl-CoA is regulated acutely (in minutes) by changes in the activity of the beta-isoform of acetyl-CoA carboxylase (ACCbeta). This can occur by at least two mechanisms: one involving cytosolic citrate, an allosteric activator of ACCbeta and a… CONTINUE READING
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