Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture.

@article{Maher1994MalondialdehydeSC,
  title={Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture.},
  author={Jacquelyn J. Maher and Charidimos Tzagarakis and A. Gim{\'e}nez Gim{\'e}nez},
  journal={Alcohol and alcoholism},
  year={1994},
  volume={29 5},
  pages={605-10}
}
Lipid aldehydes have been proposed as mediators of hepatic fibrosis in alcoholics. In this study we examined whether hepatic lipocytes, the principal matrix-producing cells in liver, exhibit enhanced collagen synthesis in response to the lipid aldehyde malondialdehyde. Lipocytes isolated from normal rat liver and plated in primary culture for 3 days were not affected by malondialdehyde in concentrations ranging from 2 to 200 microM. Cells cultured for 7 days displayed a modest increase in… CONTINUE READING

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