Malonate-assisted purification of human caspases.


Caspases have in the past decade become some of the most intensely pursued targets for the design of small-molecule inhibitors. Two significant technological roadblocks to developing caspase-binding molecules are the poor solubility of a subset of the bacterially expressed proteins and the instability of the renatured proteins that results from rapid… (More)


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@article{Scheer2005MalonateassistedPO, title={Malonate-assisted purification of human caspases.}, author={Justin M Scheer and James A. Wells and Michael J. Romanowski}, journal={Protein expression and purification}, year={2005}, volume={41 1}, pages={148-53} }