Malonate Inhibits Virulence Gene Expression in Vibrio cholerae

  title={Malonate Inhibits Virulence Gene Expression in Vibrio cholerae},
  author={Yusuke Minato and Sara R. Fassio and Claudia C. H{\"a}se},
  booktitle={PloS one},
We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern observed. Unlike another SDH inhibitor, 2-thenoyltrifluoroacetone (TTFA), which increased toxT transcription and slightly inhibited V. cholerae… CONTINUE READING