Malnutritional neuropathy under intestinal levodopa infusion

@article{Klostermann2011MalnutritionalNU,
  title={Malnutritional neuropathy under intestinal levodopa infusion},
  author={F. Klostermann and Constanze Jugel and T. M{\"u}ller and F. Marzinzik},
  journal={Journal of Neural Transmission},
  year={2011},
  volume={119},
  pages={369-372}
}
Levodopa/Carbidopa intestinal gel infusion (LCIG) for Parkinson’s disease is under debate to provoke polyneuropathy (PNP). In our cohort of 20 thus treated patients, two developed debilitating axonal PNP with deficient pyridoxin and folate levels, and marginal cobalamin. Homocysteine was highly elevated. The neuropathies responded to vitamin replacement. We assume that LCIG can provoke PNP most likely of malnutritional origin. To avoid this side effect, the assessment of predisposing factors… Expand
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