Mallotus philippinensis bark extracts promote preferential migration of mesenchymal stem cells and improve wound healing in mice.

@article{Furumoto2014MallotusPB,
  title={Mallotus philippinensis bark extracts promote preferential migration of mesenchymal stem cells and improve wound healing in mice.},
  author={Tadashi Furumoto and Noriyasu Ozawa and Yuta Inami and Misaki Toyoshima and Kosuke Fujita and Kaori Zaiki and Shunya Sahara and Mariko Akita and Keiko Kitamura and Koichi Nakaoji and Kazuhiko Hamada and Katsuto Tamai and Yasufumi Kaneda and Akito Maeda},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2014},
  volume={21 3},
  pages={247-53}
}
In the present study, we report the effects of the ethanol extract from Mallotus philippinensis bark (EMPB) on mesenchymal stem cell (MSC) proliferation, migration, and wound healing in vitro and in a mouse model. Chemotaxis assays demonstrated that EMPB acted an MSC chemoattractant and that the main chemotactic activity of EMPB may be due to the effects of cinnamtannin B-1. Flow cytometric analysis of peripheral blood mononuclear cells in EMPB-injected mice indicated that EMPB enhanced the… CONTINUE READING
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