Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.

  title={Mallotoxin is a novel human ether-a-go-go-related gene (hERG) potassium channel activator.},
  author={Haoyu Zeng and Irina M. Lozinskaya and Zuojun Lin and Robert N. Willette and David P. Brooks and Xiaoping Xu},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={319 2},
Human ether-a-go-go-related gene (hERG) encodes a rapidly activating delayed rectifier potassium channel that plays important roles in cardiac action potential repolarization. Although many drugs and compounds block hERG channels, activators of the channel have only recently been described. Three structurally diverse synthetic compounds have been reported to activate hERG channels by altering deactivation or inactivation or by unidentified mechanisms. Here, we describe a novel, naturally… CONTINUE READING
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