Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).

@article{Worby2008MalinDG,
  title={Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG).},
  author={Carolyn A. Worby and Matthew S. Gentry and Jack E. Dixon},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 7},
  pages={4069-76}
}
Lafora disease (LD) is an autosomal recessive neurodegenerative disease that results in progressive myoclonus epilepsy and death. LD is caused by mutations in either the E3 ubiquitin ligase malin or the dual specificity phosphatase laforin. A hallmark of LD is the accumulation of insoluble glycogen in the cytoplasm of cells from most tissues. Glycogen metabolism is regulated by phosphorylation of key metabolic enzymes. One regulator of this phosphorylation is protein targeting to glycogen (PTG… CONTINUE READING