Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel

  title={Malignant transformation of primary chicken spleen cells by human transcription factor c-Rel},
  author={Thomas D. Gilmore and Catherine Cormier and Jims Jean-Jacques and Maria-Emily R Gapuzan},
Rel/NF-κB transcription factors control a variety of cellular processes, such as cell growth and apoptosis, that are relevant to oncogenesis, and mutations in genes encoding Rel/NF-κB transcription factors have been found in several human lymphoid cell cancers. In this study, we have used a sensitive cell outgrowth assay to demonstrate that wild-type human c-Rel can malignantly transform primary chicken spleen cells, and that transformation by c-Rel is accelerated by co-expression of Bc1-2… CONTINUE READING


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