Malignant transformation of intracranial mature teratoma to yolk sac tumor after late relapse. Case report.

@article{Utsuki2007MalignantTO,
  title={Malignant transformation of intracranial mature teratoma to yolk sac tumor after late relapse. Case report.},
  author={Satoshi Utsuki and Hidehiro Oka and Takao Sagiuchi and Satoru Shimizu and Sachio Suzuki and Kiyotaka Fujii},
  journal={Journal of neurosurgery},
  year={2007},
  volume={106 6},
  pages={
          1067-9
        }
}
The recurrence of intracranial mature teratomas as germ cell tumors of different histological types is rarely reported. The authors describe the first case of the malignant transformation of an intracranial mature teratoma into a yolk sac tumor in a 16-year-old boy who presented with a 1-month history of anorexia and somnolence. Seven years prior to this presentation, the boy had undergone surgery for extirpation of a mature pineal teratoma. Computed tomography images obtained at his second… 
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A rare case involving the occurrence of metachronous pure germinomas long after treatment of a mixed germ cell tumor (GCT) categorized as having a poor prognosis indicates the possibility of multicentric GCTs in the CNS.
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The aim of this paper is to report the clinical and pathological findings, the surgical approach and the long-term biological behaviour in these cases, in the light of survival and current insights reported in the literature.
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