Malignant transformation in non-irradiated juvenile laryngeal papillomatosis

  title={Malignant transformation in non-irradiated juvenile laryngeal papillomatosis},
  author={Elisabeth Rehberg and Oskar Kleinsasser},
  journal={European Archives of Oto-Rhino-Laryngology},
A spontaneous cancer transformation of non-irradiated juvenile papillomas has been observed in a very small number of cases. We report on six more patients with juvenile laryngeal papillomatosis developing into a squamous-cell carcinoma. Three patients had childhood papillomatosis and three patients adult onsets of their papillomas. The average duration between onset of papillomatosis and cancer diagnosis was 33 years, while the average age at time of diagnosis of a laryngeal cancer was 50… CONTINUE READING