Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.

@article{Koromilas1992MalignantTB,
  title={Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.},
  author={Antonis E. Koromilas and Shukla Roy and Glen N Barber and Michael G. Katze and Nahum Sonenberg},
  journal={Science},
  year={1992},
  volume={257 5077},
  pages={1685-9}
}
The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the physiological function of the kinase suggest that it participates in cell growth and differentiation by regulating protein synthesis. Autophosphorylation and consequent activation of dsRNA-PK in vitro and in vivo result in phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2) and… CONTINUE READING