Malignant peripheral nerve sheath tumor arising in a "de novo" ganglioneuroma: a case report and review of the literature.

@article{Drago1997MalignantPN,
  title={Malignant peripheral nerve sheath tumor arising in a "de novo" ganglioneuroma: a case report and review of the literature.},
  author={Gaspare Drago and Basile M. Pasquier and Dominique Pasquier and Nicole Pinel and V Rouault-Plantaz and Jean François Dyon and Chantal Durand and Corinne Armari-Alla and Dominique Plantaz},
  journal={Medical and pediatric oncology},
  year={1997},
  volume={28 3},
  pages={
          216-22
        }
}
A case of a "de novo" ganglioneuroma showing a large area of malignant peripheral nerve sheath tumor (MPNST) is described. The tumor arose in an 11.5-year-old girl with neither stigmata nor family history of von Recklinghausen's neurofibromatosis. In addition, the patient had no previous history of a neuroblastoma or radiation therapy. This report provides new evidence that, although rare, the spontaneous development of an MPNST in a benign ganglioneuroma can occur. Immunohistochemical and… CONTINUE READING
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