Malignant paraganglioma caused by a novel germline mutation of the succinate dehydrogenase D-gene--a case report.

Abstract

BACKGROUND Paragangliomas of the head and neck are rare, mostly benign tumors. Approximately 10% to 15% of paragangliomas are caused by mutations in the succinate dehydrogenase (SDH) genes B, C, or D. These are often multifocal as part of paraganglioma syndromes and hormone secreting, and malignant particularly associated with mutations in SDHB. METHODS… (More)
DOI: 10.1002/hed.20746

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