Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes

  title={Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes},
  author={Melissa Halpern Fowler and Jason Fowler and Barbara S. Ducatman and Leon Barnes and Jennifer Leigh Hunt},
  journal={Modern Pathology},
Carcinosarcomas and carcinoma ex pleomorphic adenoma of the salivary glands are rare tumors that fit into the broader category of malignant mixed tumors. Although most evidence has suggested that the different morphologic components arise from a common clonal origin, there are very few studies that have provided molecular evidence for this clonality. In this study, we examined a set of seven carcinosarcomas and four carcinomas ex pleomorphic adenoma for tumor suppressor gene loss of… CONTINUE READING


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