Malignant melanoma and extramammary Paget's disease in the same patient.

@article{Manabe1985MalignantMA,
  title={Malignant melanoma and extramammary Paget's disease in the same patient.},
  author={Toshiaki Manabe and Takafumi Moriya and Yoshiaki Inagaki and Yoshifumi Takei},
  journal={The American Journal of dermatopathology},
  year={1985},
  volume={7 Suppl},
  pages={29-34}
}
Axillary Paget's disease was found in a 34-year-old man who died of metastatic malignant melanoma. The primary cutaneous malignant melanoma was diagnosed 6 years before the patient's demise and was confirmed by the presence of melanin, a positive dopa reaction, and immunohistochemical demonstration of S-100 protein in neoplastic cells. Postmortem examination revealed Paget's disease of the axillary skin in addition to widespread metastases of malignant melanoma. Paget cells were positive for… CONTINUE READING

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