Malignant hyperthermia.

@article{Wappler2001MalignantH,
  title={Malignant hyperthermia.},
  author={Frank Wappler},
  journal={European journal of anaesthesiology},
  year={2001},
  volume={18 10},
  pages={632-52}
}
  • Frank Wappler
  • Published 2001 in European journal of anaesthesiology
Malignant hyperthermia is an autosomal-dominant inherited disorder of the skeletal muscle cell characterized by a hypermetabolic response to all commonly used inhalational anaesthetics and depolarizing muscle relaxants. The clinical syndrome includes muscle rigidity, hypercapnia, tachycardia and myoglobinuria as result of increased carbon dioxide production, oxygen consumption and muscle membrane breakdown. In human beings and animals susceptible to malignant hyperthermia, it is generally… CONTINUE READING

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