Malignant clonal expansion of large granular lymphocytes with a Leu-11+, Leu-7- surface phenotype: in vitro responsiveness of malignant cells to recombinant human interleukin 2.

@article{Koizumi1986MalignantCE,
  title={Malignant clonal expansion of large granular lymphocytes with a Leu-11+, Leu-7- surface phenotype: in vitro responsiveness of malignant cells to recombinant human interleukin 2.},
  author={Shoichi Koizumi and Hidetoshi Seki and T Tachinami and Masaru Taniguchi and Akio Matsuda and Keijiro Taga and Takayuki Nakarai and Eriko Kato and Nobuhiro Taniguchi and Hiroshi Nakamura},
  journal={Blood},
  year={1986},
  volume={68 5},
  pages={1065-73}
}
A 14-year-old Japanese female with neutropenia showed malignant proliferation of the large granular lymphocytes (LGLs). These LGLs were E rosette+ and Fc(IgG) receptor+ and therefore are referred to as T gamma lymphocytes. They were also Leu-11+ and OKT11+; however, they were clearly negative for Leu-7, OKT3, OKT8, OKM1, and HNK-1 antigens as well as for terminal deoxynucleotidyl transferase activity. Karyotype analysis revealed 47, XXX. The LGLs showed no rearrangement of T cell receptor C… CONTINUE READING