Malignant bone pain: pathophysiology and treatment

@article{Mercadante1997MalignantBP,
  title={Malignant bone pain: pathophysiology and treatment},
  author={Sebastiano Mercadante},
  journal={Pain},
  year={1997},
  volume={69},
  pages={1-18}
}
Abstract The presence of bone metastases predicts the presence of pain and is the most common cause of cancer‐related pain. Although bone metastases do not involve vital organs, they may determine deleterious effects in patients with prolonged survival. Bone fractures, hypercalcaemia, neurologic deficits and reduced activity associated with bone metastases result in an overall compromise in the patient's quality of life. A metastasis is a consequence of a cascade of events including a… Expand
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