Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy.

@article{Liang1991MalignantAF,
  title={Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy.},
  author={Bertrand C. Liang and Allan F. Thornton and Howard M. Sandler and Harry S. Greenberg},
  journal={Journal of neurosurgery},
  year={1991},
  volume={75 4},
  pages={
          559-63
        }
}
Hochberg and Pruitt have reported glioblastomas recurring within 2 cm of the primary site in 90% of patients after whole-brain radiation therapy. They suggested that computerized tomography (CT) scan accuracy would permit smaller radiation fields. A treatment protocol with smaller-field focal brain irradiation following surgical resection is reported. The first 4500 cGy of radiation is focused to within a 3-cm margin around the tumor, with a 1500-cGy boost within a 1.5-cm margin. Forty-two… 
View on PubMed
thejns.org
180 Citations
Highly Influential Citations
4
Background Citations
36
Methods Citations
6
Results Citations
2

180 Citations

Citation Type

Citation Type

Patterns of recurrence of glioblastoma multiforme after external irradiation followed by implant boost.
Patterns of imaging failures in glioblastoma patients treated with chemoradiation: a retrospective study
TLDR
While local failure predominated, distant failures were not uncommon, particularly at later time points; further study is needed to identify and appropriately treat patients susceptible to distant failure.
Treatment of Glioblastoma Multiforme by Stereotactic Radio Therapy/Intensity Modulated Radiation Therapy
Hypofractionated stereotactic radiation therapy for recurrent glioblastoma: single institutional experience
TLDR
The results suggest that hypofractionated stereotactic radiation therapy is effective and safe in recurrent GBM, and until prospective randomized trials will confirm these results, the decision for salvage treatment should remain individual and based on a multidisciplinary evaluation of each patient.
Results of re-irradiation of primary intracranial neoplasms with three-dimensional conformal therapy.
TLDR
Re-irradiation with highly conformal three-dimensional planning provides frequent clinical improvement with acceptable morbidity and should be considered in selected patients with recurrent intracranial neoplasms.
3D-recurrence-patterns of glioblastomas after CT-planned postoperative irradiation.
Low grade gliomas: preliminary analysis of failure patterns among patients treated using 3D conformal external beam irradiation.
  • A. Pu, H. Sandler, +5 authors D. Ross
  • Medicine, Physics
    International journal of radiation oncology, biology, physics
  • 1995
Delineation of radiation therapy target volumes for patients with postoperative glioblastoma: a review
TLDR
Smaller RT fields may be more appropriate than larger RT fields, possibly reducing the risk of late neurological deterioration, especially in patients with significant peritumoral edema, according to a review of factors influencing target delineation.
Permanent iodine 125 brachytherapy in patients with progressive or recurrent glioblastoma multiforme.
TLDR
It is concluded that permanent 125I brachytherapy for recurrent or progressive glioblastoma multiforme (GM) is well tolerated and Survival time was comparable to that of a similar group of patients treated with temporary brachyTherapy.
The Definition and Delineation of the Target Area of Radiotherapy Based on the Recurrence Pattern of Glioblastoma After Temozolomide Chemoradiotherapy
TLDR
This study focuses on the recurrence pattern of GBM patients whose target delineations did not intentionally include the T2/fluid-attenuated inversion recovery (FLAIR) hyperintensity area outside of the gross tumor volume (GTV).
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma.
Radiation therapy treatment planning in supratentorial glioblastoma multiforme: an analysis based on post mortem topographic anatomy with CT correlations.
Assumptions in the radiotherapy of glioblastoma
TLDR
CT scan accuracy may permit smaller-field and higher-dose irradiation therapy for glioblastoma, and current radiation doses would appear to be inadequate for therapy of the primary tumor.
Regrowth patterns of glioblastoma multiforme related to planning of interstitial brachytherapy radiation fields.
TLDR
Three patterns of computed tomographic scan-documented tumor regrowth were recognized: preferential, circumferential, and away (local regrowth into noncontiguous brain, sparing the surgical bed), which indicate radiation fields planned for interstitial brachytherapy must adequately include the resected area.
Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas.
TLDR
Considering the high frequency of intellectual dysfunction after whole-brain radiation therapy, the use of focal radiation fields appears to be the most judicious approach to the treatment of patients with gliomas.
The spread of glioblastoma multiforme as a determining factor in the radiation treated volume.
  • O. Salazar, P. Rubin
  • Medicine
    International journal of radiation oncology, biology, physics
  • 1976
Radiation therapy in the treatment of glioblastoma.
TLDR
Radiation therapy can prolong the survival time of those with glioblastoma, but a high tumor dose of more than 6,000 rads or 1,700 rets is necessary to improve the prognosis significantly.
Three-dimensional treatment planning of astrocytomas: a dosimetric study of cerebral irradiation.
Radiation therapy of brain tumors
TLDR
Results of radiation therapy obtained at the University of California, San Francisco, over approximately the past 20 years for various histologic types of brain tumors are presented, and it is possible that permanent control of many intracranial neoplasms may be induced by radiation therapy.
Treatment of glioblastoma multiforme. A review.
TLDR
Adding BCNU (or perhaps tri-iodothyronine) to medium field and moderate dose irradiation may improve the outlook for patients with glioblastoma multiforme and an expanded controlled clinical trial to assess this promise of improved treatment results seems indicated.
...
1
2
3
...