Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.

@article{Santos1984MalignantAO,
  title={Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.},
  author={Eugerio Santos and Dionisio Mart{\'i}n-Zanca and E. P. Reddy and Marco Alessandro Pierotti and Giovanna Della Porta and Mariano Barbacid},
  journal={Science},
  year={1984},
  volume={223 4637},
  pages={661-4}
}
A single genetic alteration, a guanine-to-cytosine transversion, is responsible for the acquisition of malignant properties by K-ras genes of two human tumor cell lines established from carcinomas of the bladder (A1698) and lung (A2182). As a consequence, arginine instead of the normal glycine is incorporated into the K-ras-coded p21 proteins at amino acid position 12. This mutation creates a restriction enzyme polymorphism that can be used to screen human cells for transforming K-ras genes… CONTINUE READING
106 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 106 extracted citations

Similar Papers

Loading similar papers…