Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma.

Abstract

Aneurysmal bone cysts are uncommon primary bone tumors typically regarded as histologically and clinically benign. Malignant transformation of these lesions occurs almost exclusively in the context of prior radiation exposure. However, 4 cases of an osteosarcoma developing without prior radiation exposure have been reported. In this article, we report a fifth case of degeneration of an aneurysmal bone cyst to a fibroblastic osteosarcoma. In addition to reviewing the earlier cases, we describe the radiologic, pathologic, and immunohistochemical basis of this diagnosis.

Cite this paper

@article{Kansagra2016MalignantTO, title={Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma.}, author={Akash P Kansagra and Jennifer J. Wan and Kavi K Devulapalli and Andrew E Horvai and Richard J O'Donnell and Thomas M. Link}, journal={American journal of orthopedics}, year={2016}, volume={45 6}, pages={E367-E372} }