Malignant Catarrhal Fever of Cattle Is Associated with Low Abundance of IL-2 Transcript and a Predominantly Latent Profile of Ovine Herpesvirus 2 Gene Expression

@inproceedings{MeierTrummer2009MalignantCF,
  title={Malignant Catarrhal Fever of Cattle Is Associated with Low Abundance of IL-2 Transcript and a Predominantly Latent Profile of Ovine Herpesvirus 2 Gene Expression},
  author={Claudia S. Meier-Trummer and Hubert Rehrauer and Marco Franchini and Andrea Patrignani and Ulrich Wagner and Mathias Ackermann},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Malignant catarrhal fever (MCF) is a lethal disease of cattle, characterized by vasculitis, necrosis, and accumulation of activated, dysregulated cytotoxic lymphocytes in various tissues. Ovine gamma herpesvirus 2 (OvHV-2) is a causative agent of MCF, which may trigger the disease through immunopathogenic pathways. Lymphocytes are the main target of the virus. However, the pathogenic basis of the disease is still mysterious. METHODS/FINDINGS We hypothesized that the gene expression… CONTINUE READING

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