Malignancy in coeliac disease--effect of a gluten free diet.

  title={Malignancy in coeliac disease--effect of a gluten free diet.},
  author={Geoffrey K.T. Holmes and Pat Prior and M. R. Lane and Daniel Pope and Robert N. Allan},
  pages={333 - 338}
Two hundred and ten patients with coeliac disease previously reported from this unit were reviewed at the end of 1985 after a further 11 years of follow up. The initial review at the end of 1974 could not demonstrate that a gluten free diet (GFD) prevented these complications, probably because the time on diet was relatively short. The same series has therefore been kept under surveillance with the particular aim of assessing the effects of diet on malignancy after a further prolonged follow up… 
Malignancy in unrecognised coeliac disease: a nail in the coffin for mass screening?
It is reported that the long-term follow-up of a cohort of 210 patients with coeliac disease showed that the risks of developing EATL were much lower in those taking a strict GFD, although the term ‘strict’ was not clearly defined in their paper.
Need for follow up in coeliac disease.
It is suggested that a histologically confirmed diagnosis of coeliac disease and regular lifelong follow up are essential in the management of these patients.
The implications of recent advances in coeliac disease
Research into coeliac disease continues on several fronts to elucidate the genetic influences on disease inheritance, the “toxic” antigen within gliadin and the immunopathogenic mechanisms occurring within the small bowel mucosa.
Compliance of adolescents with coeliac disease with a gluten free diet.
A cohort of 123 patients with coeliac disease, diagnosed in the first three years of life and followed up for at least 10 years, was reevaluated during the teenage period in terms of compliance with
disease with a gluten free diet . Compliance of adolescents with coeliac
A cohort of 123 patients with coeliac disease, diagnosed in the first three years of life and followed up for at least 10 years, was reevaluated during the teenage period in terms of compliance with
Association Between Celiac Disease and Cancer
A considerable number of studies have considered the possible association between CD and neoplasms and an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported.
Effect of a Gluten-free Diet on the Risk of Enteropathy-associated T-cell Lymphoma in Celiac Disease
Results show that a strict gluten-free diet is protective towards the development of enteropathy-associated T-cell lymphoma.
Compliance With Gluten-free Diet in Children With Coeliac Disease
Almost half of the coeliac patients were likely to abandon GFD without experiencing major symptoms, thus increasing the risk for developing complications later in life.
Coeliac Disease in the Elderly
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Cystosarcoma phyllodes of the breast occurring in a child with subsequent diagnosis of celiac disease.
It is suggested that malignancy in childhood celiac disease is underreported and a young woman who, at age 10 years, had a sarcoma (cystosarcoma phyllodes) removed from her right breast is reported.


Coeliac disease, gluten-free diet, and malignancy.
Two hundred and two patients with coeliac disease or idiopathic steatorrhoea previously reported from this unit have been reviewed after a further 10 years of follow-up and there was no evidence that patients showing sub-optimal clinical response to gluten withdrawal or persisting falt jejunal biopsies were more prone to die of cancer.
Coeliac disease and lymphoma.
Following the original description of lymphoma complicating coeliac disease [1], it has become clear that patients with coeliac disease have a 50to a 100-fold increased risk of developing malignant
Lymphoma risk in coeliac disease of later life.
It is concluded that lymphoma is particularly a complication of older coeliacs and that coeliats newly diagnosed at more than 50 years of age should be more closely followed up for they have a 1 in 10 chance of harbouring a lymphoma.
Adenocarcinoma of the upper small bowel complicating coeliac disease.
Four more patients with this association with Adenocarcinoma of the small intestine complicating coeliac disease are described, confirmed in three by jejunal biopsy over five years before the diagnosis of malignancy.
The clinical and biochemical syndrome in lymphadenoma and allied diseases involving the mesenteric lymph glands.
There is no reliable evidence that mesenteric lymphatic obstruction constitutes the basis of defective intestinal absorption in sprue, idiopathic steatorrhoea, or coeliac disease, but it appears to underlie the clinical and biochemical picture shown in the present series of Mesenteric adenopathies.
The jejunal cellular infiltrate in coeliac disease complicated by lymphoma
The results suggest that the immunological status of coeliac patients with lymphoma differs from that of other co-eliacs and it could represent a primary abnormality and also be relevant to the development of lymphoma.
Malignant Diseases and Mortality Rate
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Malignant histiocytosis of the intestine: the early histological lesion.
A histological study of peroral jejunal biopsies and resection specimens from patients with malignant histiocytosis of the intestine (MHI) has revealed characteristic lesions consisting of