Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents.

  title={Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents.},
  author={Kai Lehmberg and Bj{\"o}rn Sprekels and Kim E Nichols and Wilhelm Woessmann and Ingo M{\"u}ller and Meinolf Suttorp and Toralf Bernig and Karin Beutel and Sebastian F N Bode and Karim Kentouche and Reinhard Kolb and Alfred Laengler and Milen Minkov and Freimut H. Schilling and Irene Schmid and Simon Vieth and Stephan Ehl and Udo zur Stadt and Gritta E. Janka},
  journal={British journal of haematology},
  volume={170 4},
Haemophagocytic lymphohistiocytosis (HLH) in the context of malignancy is mainly considered a challenge of adult haematology. While this association is also observed in children, little is known regarding inciting factors, appropriate treatment and prognosis. We retrospectively analysed 29 paediatric and adolescent patients for presenting features, type of neoplasm or preceding chemotherapy, treatment and outcome. Haemophagocytic lymphohistiocytosis was considered triggered by the malignancy (M… CONTINUE READING
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