Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review

  title={Malfunctioning of the autonomic nervous system in patients with chronic fatigue syndrome: a systematic literature review},
  author={D Van Cauwenbergh and Jo Nijs and Daphne Kos and Laura Weijnen and Filip Struyf and Mira Meeus},
  journal={European Journal of Clinical Investigation},
  pages={516 - 526}
It is hypothesised that the autonomic nervous system responds differently to various stressors in patients with chronic fatigue syndrome (CFS) compared with healthy controls. The goal is to systematically review the scientific literature addressing the functioning of the autonomic nervous system in patients with CFS. 

Differential Diagnosis of Vasovagal Syncope: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Fatigue is a frequent symptom in the general population, being reported by up to 50 % of the respondents to large-scale surveys, and may also accompany psychiatric conditions such as depression, panic disorder, or somatization.

Central Autonomic Network Disturbance in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Pilot Study

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease of the central nervous system known to be associated with multiple behavioral symptoms (fatigue, low stamina,

Autonomic Phenotypes in Chronic Fatigue Syndrome (CFS) Are Associated with Illness Severity: A Cluster Analysis

Those with a sympathetic-dysautonomia phenotype were associated with more severe disease, reported greater subjective autonomic symptoms with sympathetic over-modulation and had the lowest quality of life.

Self-management and ambulatory monitoring in chronic fatigue syndrome: future directions

This editorial focuses on ideas to improve self-management and discusses the related issue of ambulatory monitoring, a methodology that can be used to better understand the highly variable symptom profiles in patients with CFS.

The aetiopathogenesis of fatigue: unpredictable, complex and persistent

It is suggested that an approach based on non-determinism, non-reductionism and self-organization may afford a coherent explanatory framework for much of the observed phenomena in fatigue and offers promising avenues for future research.

Causes and consequences of autonomic dysfunction in Chronic Fatigue Syndrome

It is suggested that elucidating the symptoms seen in CFS will support research into its underlying pathophysiology and enable more tailored treatment, and the need to better understand the underpinning causality to allow appropriate identification and management.

Chronic Fatigue Syndrome (CFS) or “Systemic Immune Disorder” (SID)?

In the opinion of the authors an acceptable therapeutic result can commonly be attained by combining meditation, such as mindfulness, adaptation of lifestyle and nutrition, with complementary food supplementation using nutriceuticals and plant extracts.

Chronic fatigue syndrome: progress and possibilities

A growing body of evidence suggests CFS arises from functional (non‐structural) changes in the brain, but of uncertain character and location, and there is significant room for improvement in provision of the diagnosis and supportive care.

Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndrome

The differences in HR parameters identified by the meta-analysis indicate that ME/CFS patients have altered autonomic cardiac regulation when compared to healthy controls, which may be symptomatic of the condition.

The sympathetic nervous system regulates skeletal muscle motor innervation and acetylcholine receptor stability

The interaction between the sympathetic and motor nervous system, the involvement of the sympathetic nervous system in neuromuscular junction presynaptic motor function, the stability of postsynaptic molecular organization, and the skeletal muscle composition and function are examined.



Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome

A significant proportion of patients with chronic fatigue syndrome (CFS) also have postural orthostatic tachycardia syndrome (POTS). We aimed to characterize these patients and differentiate them

The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group.

This work proposes a conceptual framework and a set of guidelines that provide a comprehensive, systematic, and integrated approach to the evaluation, classification, and study of persons with this condition and other fatiguing illnesses.

Abnormal Thermoregulatory Responses in Adolescents With Chronic Fatigue Syndrome: Relation to Clinical Symptoms

Adolescent patients with chronic fatigue syndrome have abnormal catecholaminergic-dependent thermoregulatory responses both at rest and during local skin cooling, supporting a hypothesis of sympathetic dysfunction and possibly explaining important clinical symptoms.

Clinical Disorders of the Autonomic Nervous System Associated with Orthostatic Intolerance: An Overview of Classification, Clinical Evaluation, and Management

  • B. GrubbB. Karas
  • Medicine, Psychology
    Pacing and clinical electrophysiology : PACE
  • 1999
On going studies will continue to help better define the broad spectrum of these disorders, and to elaborate better diagnostic and treatment modalities.

Hemodynamics instability score in chronic fatigue syndrome and in non-chronic fatigue syndrome.

The cardiovascular reactivity in patients with CFS has certain features in common with the reactivity with patients with recurrent syncope or non-CFS chronic fatigue, such as the frequent occurrence of vasodepressor reaction, cardioinhibitory reaction, and postural tachycardia syndrome.

The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study

We have developed a conceptual framework and a set of research guidelines for use in studies of the chronic fatigue syndrome. The guidelines cover the clinical and laboratory evaluation of persons

Autonomic function in patients with chronic fatigue syndrome

There were no significant differences between CFS patients with and without symptoms of autonomic dysfunction regarding the hemodynamic responses to the cardiovascular reflex tests, and the findings suggest that there are no gross alterations in cardiovascular autonomic function in patients with CFS.