Malformations in infants of diabetic mothers: problems in study design.

  title={Malformations in infants of diabetic mothers: problems in study design.},
  author={Joseph L R Mills and A R Fishl and R. Knopp and C L Ober and Lois Jovanovi{\vc} and B. Frank Polk},
  journal={Preventive medicine},
  volume={12 2},
Infants of diabetic mothers have a two- to threefold increased risk of having congenital malformations. Primary prevention of these malformations may be possible if the teratogenic mechanisms in diabetes can be identified. The Diabetes in Early Pregnancy Study (DIEP) addresses the questions of high malformation rates and fetal losses using an innovative study design. Women are recruited prior to pregnancy, monitored to ensure prompt diagnosis of pregnancy, and followed carefully for diabetic… CONTINUE READING