Maleate induced fall of glomerular filtration rate. A micropuncture study in the rat.

@article{Leser1985MaleateIF,
  title={Maleate induced fall of glomerular filtration rate. A micropuncture study in the rat.},
  author={Karl H. Leser and Hartmut Osswald},
  journal={Naunyn-Schmiedeberg's archives of pharmacology},
  year={1985},
  volume={331 2-3},
  pages={253-9}
}
Maleate causes an enhanced excretion of amino acids, glucose, phosphate and bicarbonate. In addition to this inhibition of fluid and electrolyte reabsorption malate decreases glomerular filtration rate (GFR). The present investigation was designed to study the mechanisms of this fall in GFR. In group I (Sprague-Dawley rats; N = 8) maleate (2 mmol/kg body weight i.v.) increased the hydrostatic pressure in proximal tubule from 12.6 +/- 0.5 to 16.3 +/- 0.8 mm Hg (mean + SEM) and stop flow pressure… CONTINUE READING

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