Male-to-female sex reversal in M33 mutant mice

@article{KatohFukui1998MaletofemaleSR,
  title={Male-to-female sex reversal in M33 mutant mice},
  author={Yuko Katoh-Fukui and Reiko Tsuchiya and Toshihiko Shiroishi and Y Nakahara and N Hashimoto and Kousei Noguchi and Toru Higashinakagawa},
  journal={Nature},
  year={1998},
  volume={393},
  pages={688-692}
}
Polycomb genes in Drosophila maintain the repressed state of homeotic and other developmentally regulated genes by mediating changes in higher-order chromatin structure. M33, a mouse homologue of Polycomb, was isolated by means of the structural similarity of its chromodomain. The fifth exon of M33 contains a region of homology shared by Drosophila and Xenopus,. In Drosophila, its deletion results in the loss of Polycomb function. Here we have disrupted M33 in mice by inserting a poly(A… Expand
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