Male-specific modification of human CD52.

  title={Male-specific modification of human CD52.},
  author={Sabine Schr{\"o}ter and Petra Derr and Harald S. Conradt and Manfred Nimtz and Geoffrey Hale and Christiane Kirchhoff},
  journal={The Journal of biological chemistry},
  volume={274 42},
CD52 is an unusually short, bipolar glycopeptide bearing a highly charged N-linked carbohydrate moiety and a glycosylphosphatidylinositol membrane anchor. It is exclusively expressed on lymphocytes and in the male genital tract where it is shed into the seminal plasma and inserts into the sperm membrane. The sperm surface molecule has potential significance as a target for antibodies that inhibit sperm function and gamete interaction. Western blot analyses suggested cell type-specific… CONTINUE READING


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