Male-specific expression of mouse sex-limited protein requires growth hormone, not testosterone.

@article{Georgatsou1993MalespecificEO,
  title={Male-specific expression of mouse sex-limited protein requires growth hormone, not testosterone.},
  author={E Georgatsou and P Bourgarel and Tommaso Di Meo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 8},
  pages={3626-30}
}
Sex-limited protein (Slp), an isoform of mouse complement component C4, is expressed predominantly in liver and nearly exclusively in sexually mature males or testosterone-treated females. It is encoded by a gene (C4-Slp) whose hormonal dependence has been attributed to an androgen-responsive transcriptional enhancer introduced accidentally, alongside the C4-Slp promoter, in the guise of the 5' long terminal repeat of an ancient retrovirus. We demonstrate that the pronounced rise of C4-Slp mRNA… CONTINUE READING