Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene.

@article{Laing2000MaleSD,
  title={Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene.},
  author={Michael A. Laing and Scott A Coonrod and Barry T Hinton and John Downie and Richard G. Tozer and Michael Rudnicki and John A. Hassell},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 24},
  pages={9337-45}
}
PEA3, a member of the Ets family of transcriptional regulatory proteins, is expressed in a unique spatial and temporal pattern during mouse embryogenesis; its overexpression is positively correlated with HER2-mediated breast tumorigenesis in both humans and mice. To determine whether PEA3 plays a part in development and oncogenesis and to uncover its normal physiological role, we generated mice lacking functional PEA3 by gene targeting in embryonic stem cells. PEA3(-/-) mice arose from… CONTINUE READING

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