Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22

  title={Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22},
  author={Akash Sharma and Svenia D. Heinze and Yanli Wu and Tea Kohlbrenner and Ian Morilla and Claudia Brunner and Ernst A. Wimmer and Louis van de Zande and Mark D. Robinson and Leo W. Beukeboom and Daniel Bopp},
  pages={642 - 645}
Disrupting housefly gene reverses sex Sex comes in many forms, even when considered at the molecular level. In different animals, the chromosomes and specific genes that function in sex determination vary widely. As a case in point, the familiar housefly displays a highly variable sex determination system. In this animal, the male determiner (M-factor) instructs male development when it is active, but female development results when it is inactive. Sharma et al. now identify the housefly M… 

A conserved role of the duplicated Masculinizer gene in sex determination of the Mediterranean flour moth, Ephestia kuehniella

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Distinct developmental mechanisms influence sexual dimorphisms in the milkweed bug Oncopeltus fasciatus

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Characteristic and Functional Study of Intersex, a Gene Related to Female Fertility in Bemisia tabaci

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A factor to control Medfly sex

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The Sex Determination Cascade in the Silkworm

The latest findings regarding the functions and working mechanisms of genes involved in feminization and masculinization in Lepidoptera are focused on and directions for future research of sex determination in the silkworm are discussed.

Minimal Effects of Proto-Y Chromosomes on House Fly Gene Expression in Spite of Evidence that Selection Maintains Stable Polygenic Sex Determination

The results suggest that, if natural selection maintains polygenic sex determination in house fly via gene expression differences, the phenotypes under selection likely depend on a small number of genetic targets.

Minimal effects of proto-Y chromosomes on house fly gene expression in spite of evidence that selection maintains stable polygenic sex determination

The results suggest that, if natural selection maintains polygenic sex determination in house fly via gene expression differences, the phenotypes under selection likely depend on a small number of genetic targets.

Identification of the sex chromosome system in a sand fly species, Lutzomyia longipalpis s.l

The results show that L. longipalpis s.l. has XY system, and the YGS method can be especially useful in situations in which no morphological difference is observed in the sex-chromosomes or when fresh specimens are not readily available.

Theme and variation in the evolution of insect sex determination.

This work has screened public genomic sequence databases for orthologs and duplicates of 25 genes involved in insect sex determination, identifying patterns of presence and absence and suggesting an inverse association of protein sequence conservation with functional conservation.

Identification and Characterization of the Masculinizing Function of the Helicoverpa armigera Masc Gene

Cloned HaMasc functions as a masculinizing gene in the H. armigera sex-determination cascade, and is shown to be a Z chromosome-linked gene since its genomic content in males was two times greater than that in females.



Musca domestica, a window on the evolution of sex-determining mechanisms in insects.

In the house fly, Sex-lethal is not involved in sex determination, and dosage compensation, if existent at all, is not coupled with sexual differentiation, which allows for more adaptive plasticity in the housefly system.

The Evolving Puzzle of Autosomal Versus Y-linked Male Determination in Musca domestica

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The mutation masculinizer (man) defines a sex-determining gene with maternal and zygotic functions in Musca domestica L.

A new mutation masculinizer is described, which has all the properties expected for a null or strongly hypomorphic allele of F: it maps to the same chromosomal location as FD, and has a sex-determining maternal effect.

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A gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae is isolated and characterized and controls male-specific splicing of the doublesex gene, which may be an invaluable tool for creation of conditional male-only transgenic Anophele strains for malaria control programs.

Sex Determination in Insects: Variations on a Common Theme

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Numerous Transitions of Sex Chromosomes in Diptera

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This work compares the current distribution of autosomal M factors in continental Europe, on a transect running from Germany to southern Italy, with the distribution reported 25 years ago, and analyses the frequencies of the FD factor, which has not been done before for European populations.