Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22

@article{Sharma2017MaleSI,
  title={Male sex in houseflies is determined by Mdmd, a paralog of the generic splice factor gene CWC22},
  author={Akash Sharma and Svenia D. Heinze and Yanli Wu and Tea Kohlbrenner and Ian Morilla and Claudia Brunner and Ernst A. Wimmer and Louis van de Zande and Mark D. Robinson and Leo W. Beukeboom and Daniel Bopp},
  journal={Science},
  year={2017},
  volume={356},
  pages={642 - 645}
}
Disrupting housefly gene reverses sex Sex comes in many forms, even when considered at the molecular level. In different animals, the chromosomes and specific genes that function in sex determination vary widely. As a case in point, the familiar housefly displays a highly variable sex determination system. In this animal, the male determiner (M-factor) instructs male development when it is active, but female development results when it is inactive. Sharma et al. now identify the housefly M… 

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References

SHOWING 1-10 OF 40 REFERENCES

Musca domestica, a window on the evolution of sex-determining mechanisms in insects.

In the house fly, Sex-lethal is not involved in sex determination, and dosage compensation, if existent at all, is not coupled with sexual differentiation, which allows for more adaptive plasticity in the housefly system.

The Evolving Puzzle of Autosomal Versus Y-linked Male Determination in Musca domestica

This review provides a summary of the information available to date regarding the patterns of distribution of autosomal, X-linked and Y- linked M factors, the relative frequencies of the linkage of M, the changes in frequencies found in field populations, and the fitness of males with autosomal M factors vs. Y-linked M.

The mutation masculinizer (man) defines a sex-determining gene with maternal and zygotic functions in Musca domestica L.

A new mutation masculinizer is described, which has all the properties expected for a null or strongly hypomorphic allele of F: it maps to the same chromosomal location as FD, and has a sex-determining maternal effect.

Molecular Characterization of the Key Switch F Provides a Basis for Understanding the Rapid Divergence of the Sex-Determining Pathway in the Housefly

This study presents the molecular identification and characterization of F, which acts as the master switch in the housefly pathway, and provides evidence that F corresponds to the transformer ortholog in Musca (Mdtra), which, as a result of alternative processing, expresses functional products only in individuals committed to the female fate.

A male-determining factor in the mosquito Aedes aegypti

It is shown that an M-locus gene, Nix, functions as an M factor in A. aegypti, and this study provides a foundation for mosquito control strategies that convert female mosquitoes into harmless males.

A maleness gene in the malaria mosquito Anopheles gambiae

A gene, Yob, for the M factor in the malaria mosquito Anopheles gambiae is isolated and characterized and controls male-specific splicing of the doublesex gene, which may be an invaluable tool for creation of conditional male-only transgenic Anophele strains for malaria control programs.

Sex Determination in Insects: Variations on a Common Theme

It appears that both the instructive end of the pathway upstream of tra as well as the executive end downstream of dsx are primary targets of evolutionary divergence, while the transduction part seems less prone to changes.

Numerous Transitions of Sex Chromosomes in Diptera

Many species groups, including mammals and many insects, determine sex using heteromorphic sex chromosomes. Diptera flies, which include the model Drosophila melanogaster, generally have XY sex

Are autosomal sex-determining factors of the housefly (Musca domestica) spreading north?

This work compares the current distribution of autosomal M factors in continental Europe, on a transect running from Germany to southern Italy, with the distribution reported 25 years ago, and analyses the frequencies of the FD factor, which has not been done before for European populations.