Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

@article{StanelleBertram2018MaleOB,
  title={Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood},
  author={Stephanie Stanelle-Bertram and Kerstin Walendy-Gnir{\ss} and Thomas Speiseder and Swantje Thiele and Ivy Asantewaa Asante and Carola Dreier and Nancy Mounogou Kouassi and Annette Preuss and Gundula Pilnitz-Stolze and Ursula M{\"u}ller and Stefanie Thanisch and Melanie Richter and Robin Scharrenberg and Vanessa Kraus and Ronja D{\"o}rk and Lynn Schau and Vanessa Herder and Ingo Gerhauser and Vanessa Maria Pfankuche and Christopher K{\"a}ufer and Inken Waltl and Tha{\'i}s Moraes and Julie Sellau and Stefan Hoenow and Jonas Schmidt-Chanasit and Stephanie Jansen and Benjamin Schattling and Harald Ittrich and Udo Bartsch and Thomas Renn{\'e} and Ralf Bartenschlager and Petra Clara Arck and D{\'a}niel Cadar and Manuel A. Friese and Olli Vapalahti and Hanna Lotter and Sany Benites and Lane Rolling and Martin Gabriel and Wolfgang Baumg{\"a}rtner and Fabio Morellini and Sabine M. H{\"o}lter and Oana Veronica Amarie and Helmut Fuchs and Martin Hrabě de Angelis and Wolfgang L{\"o}scher and Froylan Calderon de Anda and G{\"u}lsah Gabriel},
  journal={Nature Microbiology},
  year={2018},
  volume={3},
  pages={1161-1174}
}
Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in ~1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious… 

Subclinical in utero Zika virus infection is associated with interferon alpha sequelae and sex-specific molecular brain pathology in asymptomatic porcine offspring

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The African strain of Zika virus causes more severe in utero infection than Asian strain in a porcine fetal transmission model

This is the first large animal model study which demonstrated that African strain of ZIKV, with no passage history in experimental animals, can cause persistent infection in fetuses and fetal membranes at midgestation.

Different outcomes of neonatal and adult Zika virus infection on startle reflex and prepulse inhibition in mice

Different outcomes for the age of infection and sex in wild-type mice are identified: neonatally infected animals presented an increase in PPI and startle latency in both sexes, while adult infected males presented lower startle amplitude but preserved PPI.

Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders

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Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice.

Evaluated lipid-encapsulated mRNA vaccines and a DNA plasmid vaccine encoding the prM-E genes of ZIKV in mouse models of congenital infection, finding that the mRNA vaccines elicited higher levels of antigen-specific long-lived plasma cells and memory B cells than the DNA vaccine.

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